PARPtrap™ Combo Assay Kit for PARP1 and PARP2

78317 384 rxns.
EUR 3000
Description: The PARPtrap™ Combo Assay Kit for PARP1 and PARP2 is a kit designed to measure DNA complex formations of PARP1 and PARP2 enzymes in a high throughput screening assay using fluorescence polarization (FP). The key to the PARPtrap™ Combo Assay Kit are the fluorescent-labeled DNA probes recognized by PARP1 and PARP2. In the absence of ribosylation, PARP1/2 binds to the DNA fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after autoribosylation, PARP1/2 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP inhibitor results in trapping of PARP1/2 to the fluorescent-labeled DNA, and increases the FP signal in a dose dependent manner.The combo kit is particularly useful to directly and specifically compare, in a single assay, the effect and potency of a compound on PARP1 and PARP2. The PARPtrap™ Combo Assay Kit for PARP1 and PARP2 is a homogeneous fluorescence polarization assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.

Antibody Assay Laboratories manufactures the neutralising assay for mhv 68 antibidy reagents distributed by Genprice. The Neutralising Assay For Mhv 68 Antibidy reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact antibody assay. Other Neutralising products are available in stock. Specificity: Neutralising Category: Assay Group: For Mhv

PARPtrap™ Assay Kit for PARP2

384 rxns.
EUR 3070
Description: The PARPtrap™ Assay Kit for PARP2 is designed to measure PARP2/DNA complex formation in a high throughput screening assay using fluorescence polarization (FP). Similarly, to PARP1, PARP2 recognizes and binds damaged DNA via its DNA-binding domain. Binding to DNA activates PARP2 and in the presence of NAD+ PARP2 ribosylates itself (auto-ribosylation), which leads to PARP2 dissociation from the DNA due to the accumulated negative charge of the ribosyl polymer. In the presence of some inhibitors, however, PARP remains bound to the DNA, a phenomenon termed trapping. Trapped PARP-DNA complexes have been shown to be highly cytotoxic to cancer cells, therefore such inhibitors may be desirable for cancer treatment. The key to the PARPtrap™ Assay Kit is the fluorescent-labeled oligonucleotide duplex. In the absence of ribosylation, PARP2 binds to the fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after auto-ribosylation PARP2 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP2 inhibitor results in trapping of PARP2 to the fluorescent oligonucleotide duplex, and increases the FP signal in a dose dependent manner.The PARPtrap™ Assay Kit is a fluorescence polarization homogeneous assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.

Glycerol Assay Kit (For liquid samples)

1 Kit
EUR 735.6

PARPtrap™ Assay Kit for PARP1

96 rxns.
EUR 2145
Description: The PARPtrap™ Assay Kit for PARP1 is designed to measure PARP1/DNA complex formation in a high throughput screening assay using fluorescence polarization (FP). PARP1 is known to bind damaged DNA through its DNA-binding domains. Binding to DNA activates PARP1 and in the presence of NAD+ PARP1 ribosylates itself (auto-ribosylation), what in consequence leads to PARP1 dissociation from the DNA due to the accumulated negative charge of the ribosyl polymer. In the presence of some inhibitors, however, PARP remains bound to the DNA, a phenomenon termed trapping. Trapped PARP-DNA complexes have been shown to be highly cytotoxic to cancer cells, therefore such inhibitors may be desirable for cancer treatment.The key to the PARPtrap™ Assay Kit for PARP1 is the fluorescent-labeled oligonucleotide duplex. In the absence of ribosylation, PARP1 binds to the fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after auto-ribosylation, PARP1 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP1 inhibitor results in trapping of PARP1 to the fluorescent oligonucleotide duplex, and increases the FP signal in a dose dependent manner.The PARPtrap™ Assay Kit for PARP1 is a fluorescence polarization homogeneous assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.

PARPtrap™ Assay Kit for PARP1

384 rxns.
EUR 3070
Description: The PARPtrap™ Assay Kit for PARP1 is designed to measure PARP1/DNA complex formation in a high throughput screening assay using fluorescence polarization (FP). PARP1 is known to bind damaged DNA through its DNA-binding domains. Binding to DNA activates PARP1 and in the presence of NAD+ PARP1 ribosylates itself (auto-ribosylation), what in consequence leads to PARP1 dissociation from the DNA due to the accumulated negative charge of the ribosyl polymer. In the presence of some inhibitors, however, PARP remains bound to the DNA, a phenomenon termed trapping. Trapped PARP-DNA complexes have been shown to be highly cytotoxic to cancer cells, therefore such inhibitors may be desirable for cancer treatment.The key to the PARPtrap™ Assay Kit for PARP1 is the fluorescent-labeled oligonucleotide duplex. In the absence of ribosylation, PARP1 binds to the fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after auto-ribosylation, PARP1 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP1 inhibitor results in trapping of PARP1 to the fluorescent oligonucleotide duplex, and increases the FP signal in a dose dependent manner.The PARPtrap™ Assay Kit for PARP1 is a fluorescence polarization homogeneous assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.

ELISA kit for Mouse Hepatitis Virus (MHV)

48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Mouse Hepatitis Virus (MHV) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Hepatitis Virus (MHV)

5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Mouse Hepatitis Virus (MHV) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Hepatitis Virus (MHV)

96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Mouse Hepatitis Virus (MHV) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

For Mhv information

SARS-CoV-2 Variants Neutralizing Antibody 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

FCM-N04R 96tests
EUR 1187.7
Description: Since December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease, COVID-19, has caused a devastating pandemic worldwide.As the virus spreads globally, the continuous emergence of new mutant strains escalated the challenge on humans.To facilitate the mutant-related research, drug trials and vaccine development, a multiplex serological test for assessing antibody responses to mutant strains is in urgent need.

Soya peptone Neutralised

abx082460-400g 400 g
EUR 460.8

Neutral Protease Microplate Assay Kit

DLSM0078 100 Assays
EUR 455
Description: Detection and Quantification of Neutral Protease Activity.

Neutral Xylanase Microplate Assay Kit

DLSM0089 100 Assays
EUR 367.5
Description: Detection and Quantification of Neutral Xylanase Activity.

Neutral Invertase Microplate Assay Kit

DLSM0027 100 Assays
EUR 490
Description: Detection and Quantification of Neutral Invertase Activity.

Neutral Red Cell Cytotoxicity Assay Kit

K447-1000 each
EUR 379.2

SARS-CoV-2 Omicron Subvariants Neutralizing Antibody 5-plex Panel (Flow Cytometry Multiplex Bead Assay)

FCM-N06R 96tests
EUR 1187.7
Description: Since December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease, COVID-19, has caused a devastating pandemic worldwide. Omicron is a variant of SARS-CoV-2 first detected in November 2021 and is causing the ongoing COVID-19 pandemic. The Omicron subvariants BA.1 and BA.2 of SARS-CoV-2 have dominated the COVID-19 pandemic in early 2022. Its recent descendants BA.2.12.1 and BA.4/5 have surged dramatically to become dominant in the United States and South Africa, respectively. BA.2.12.1 and BA.4/BA.5 exhibit comparable ACE2-binding affinities to BA.2. Importantly, BA.2.12.1 and BA.4/BA.5 display stronger neutralization evasion than BA.2 against the plasma from 3-dose vaccination and, most strikingly, from post-vaccination BA.1 infections.

Neutral Phosphatase Microplate Assay Kit

DLSM0207 100 Assays
EUR 210
Description: Detection and Quantification of Acid Phosphatase Activity.

Neutral Red Cell Proliferation and Cytotoxicity Assay Kit

AR1157 1 kit (for 500 assays)
EUR 121.2

Neutral Sphingomyelinase (NSMASE) Magnetic Luminex Assay Kit

LKU603750-96T 96T
EUR 966

Neutral Sphingomyelinase (NSMASE) Magnetic Luminex Assay Kit

LKU603755-96T 96T
EUR 1048.8

Neutral Sphingomyelinase (NSMASE) Magnetic Luminex Assay Kit

LKU603758-96T 96T
EUR 993.6

Large Neutral Amino Acid Transporter 1 (LAT1) Magnetic Luminex Assay Kit

LKU602699-96T 96T
EUR 966

Sodium Coupled Neutral Amino Acid Transporter 1 (SNAT1) Magnetic Luminex Assay Kit

LKU600643-96T 96T
EUR 966

Cytomegalovirus gB Late Neutralizing Antigen (CMV-LA gB Neutralizing) Antibody

abx411283-02mg 0.2 mg
EUR 678

Cytomegalovirus gB Late Neutralizing Antigen (CMV-LA gB Neutralizing) Antibody (FITC)

abx411284-01mg 0.1 mg
EUR 610.8

Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Magnetic Luminex Assay Kit

LKU603761-96T 96T
EUR 966