Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach

Magainin Pharmaceuticals Inc. – Biopharmaceutical Research  > Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Medium & Serums, NATtrol, Particles, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Vector & Virus, Western Blot >  Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach
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Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach

Non-bioequivalent plasma focus profiles amongst totally different dosage types of the salt of raltegravir, a poorly soluble acidic drug, had been investigated utilizing biorelevant in vitro testing mixed with the business in silico software program, Simcyp®. A suspension and a pill dosage types of raltegravir potassium had been chosen because the take a look at formulations. Whereas dissolution from the suspension was fast, dissolution from the tablets was gradual and delayed by pre-exposure to an acidic surroundings.

Moreover, it was assumed that gastric emptying of the tablets could be decided by the gastric motility sample as a result of the formulation is giant and didn’t disintegrate underneath biorelevant dissolution take a look at situations. With the intention to simulate in vivo dissolution and plasma focus profiles of the tablets, in vitro and in silico trials had been carried out contemplating the gastric emptying time as a key physiological issue. The impact of pre-exposure to acid within the abdomen on dissolution conduct within the gut was estimated by two-stage in vitro dissolution testing. Primarily based on these outcomes, theoretical in vivo dissolution profiles had been generated for various gastric emptying occasions.

Plasma focus profiles for every gastric emptying time had been simulated by inputting the theoretical in vivo dissolution profiles into the in silico mannequin constructed with the scientific knowledge of the suspension. Imply plasma focus profiles of the goal topic group had been calculated, taking the distribution of particular person gastric emptying occasions into consideration. Though the pill was anticipated to have complicated in vivo dissolution conduct, plasma focus profiles had been efficiently simulated by two-stage in vitro dissolution testing and the commercially out there in silico software program when gastric emptying was taken into consideration as the important thing physiological issue. The in vitro and in silico methodology introduced on this report could be a sensible method to simulate oral absorption from numerous formulations of poorly soluble weak acids and their salts.

 

Institution of fast-growing serum-free immortalised cells from Chinese language hamster lung tissues for biopharmaceutical manufacturing

Chinese language hamster (Cricetulus griseus) ovary-derived Chinese language hamster ovary (CHO) cells are essentially the most generally used mammalian hosts for the commercial manufacturing of recombinant therapeutics due to their capability to fold, assemble, and carry out post-translational modifications, akin to glycosylation, on proteins.
They’re additionally precious for his or her capability to develop in serum-free suspension cultures. On this research, we established a cell line derived from lung tissue of Chinese language hamsters, named Chinese language hamster lung (CHL)-YN cells. The biosafety of CHL-YN cells was confirmed by in vitro sterility testing, mycoplasma detection, and reverse transcriptase assays. One of many key traits of CHL-YN cells was their doubling time of 8.1 h in chemically outlined tradition medium; thus, they proliferate a lot sooner than standard CHO cells and basic mammalian cells.
Transgenes may very well be launched into CHL-YN cells with excessive effectivity. Lastly, between 50% to > 100% of the quantity of glycosylated immunoglobulin G (IgG)1 produced by CHO-K1 cells was produced by CHL-YN cells over a shorter time frame. In abstract, fast-growing CHL-YN cells are a novel cell line for producing recombinant proteins.
 Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach
Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach

Mannequin-Knowledgeable Drug Discovery and Improvement in Pulmonary Supply: Biopharmaceutical Pharmacometric Modeling for Formulation Analysis of Pulmonary Suspensions

For respiratory situations, focused drug supply to the lungs may produce increased native concentrations with diminished danger of antagonistic occasions in comparison with systemic administration. Regardless of the rising curiosity in pulmonary supply, the pharmacokinetics (PK) of medication following pulmonary administration stays to be elucidated. On this context, the applying of modeling and simulation methodologies to characterize PK properties of compounds following pulmonary administration stays a shortage.
Pseudomonas aeruginosa (PA) lung infections are proof against most of the present antibiotic therapies. Focused remedies for pulmonary supply may very well be notably useful for these native situations. On this research, we report the applying of biopharmaceutical pharmacometrics (BPMX) for the evaluation of PK knowledge from three investigational antimicrobial brokers following pulmonary administration of a suspension formulation. The noticed drug concentration-time profiles in lungs and plasma of the compound collection had been mixed for simultaneous evaluation and modeling. The developed mannequin describes the PK knowledge, bearing in mind formulation properties, and gives a mechanism to foretell dissolved drug concentrations within the lungs out there for exercise. The mannequin was then used to guage formulation results and the influence of variability on complete and dissolved drug concentrations in lungs and plasma.

96-well Plasmid DNA Extraction Kit (2 plates)

FAPWE-96002 2 preps
EUR 225.6

96-well Plasmid ezFilter Mini Kit

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96-well Plasmid ezFilter Mini Kit

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Ultra-Fast 96-Well Plate Plasmid DNA Miniprep Kit

BS92028 2XPlates, 192prep
EUR 254.7

Ultra-Fast 96-Well Plate Plasmid DNA Miniprep Kit

BS92029 5XPlates, 480prep
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96-well Viral DNA/RNA Kit

K1417-1 each
EUR 470.4

96-well Viral DNA/RNA Kit

K1417-4 each
EUR 1227.6

96-Well Plate Plasmid DNA Mini-Preps Kit (Vacuum Based)

B814152-0002 2XPlates, 2XPlates
EUR 186.19

96-Well Plate Plasmid DNA Mini-Preps Kit (Vacuum Based)

B814152-0005 5XPlates, 5XPlates
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96-Well Plate DNA Cleanup Miniprep Kit

BS369 5XPlates, 480prep
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96-Well Plate DNA Cleanup Miniprep Kit

BS3692 2xPlates, 192prep
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96-Well Plate Viral DNA Miniprep Kit

VT92032 2XPlates, 192prep
EUR 495.86

RNA extration Kit

20-abx098086
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  • EUR 126.00
  • 100 ml
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96-well DNA–binding plates (black)

NBP96B 4 plates
EUR 77.39
Description: This product includes 4 Black 96-well plate for DNA binding and fluorescence detection

96-well DNA–binding Plates (Transparent)

NBP96T 4 plates
EUR 77.39
Description: This product includes 4 Transparent 96-well plate for DNA binding and light absorbance detection

96 well DNA plate with membrane (960ul each well)

SD5007 12UNIT
EUR 291.24

96 Well Plate Blood Genomic DNA Miniprep Kit

BT92031 2Plates, 192prep
EUR 210.85

96 Well Plate Blood Genomic DNA Miniprep Kit

BT92032 5Plates, 480prep
EUR 389.9

96-Well Plate Animal Genomic DNA Miniprep Kit

BS437 5XPlates, 480prep
EUR 435.58

96-Well Plate Animal Genomic DNA Miniprep Kit

BS4372 2XPlates, 192prep
EUR 234.6

96 Well Plate Yeast Genomic DNA Miniprep Kit

BS8357 2XPlates, 192prep
EUR 234.6

96-Well Plate Plant Genomic DNA Miniprep Kit

BS8361 2XPlates, 192prep
EUR 234.6

96-well Genomic DNA Extraction Kit (1 plates)

FADWE-96001 1 prep
EUR 189.6

96-well Genomic DNA Extraction Kit (2 plates)

FADWE-96002 2 preps
EUR 255.6

96-well Genomic DNA Extraction Kit (4 plates)

FADWE-96004 4 preps
EUR 380.4

96-Well Plate Bacteria Genomic DNA Miniprep Kit

SK1292 2XPlates, 192prep
EUR 210.85

96-Well Plate Bacteria Genomic DNA Miniprep Kit

SK1295 5XPlates, 480prep
EUR 389.9

96 Well Breast Tumor Genomic DNA Plate

D8235086-1 1 plate
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96 Well Colon Tumor Genomic DNA Plate

D8235090-1 1 plate
EUR 379.2

96 Well Lung Tumor Genomic DNA Plate

D8235152-1 1 plate
EUR 379.2

96 Well Stomach Tumor Genomic DNA Plate

D8235248-1 1 plate
EUR 379.2

Aligned Nanofibers 96 Well Plate

3D00012-96 700 nm-PCLs
EUR 132

Tissue Culture Plate, 96 Well

TCP20-96 1 UNIT
EUR 64.18

96-well Plant Genomic DNA Extraction Kit (1 plates)

FAPGE-96001 1 prep
EUR 232.8

96-well Plant Genomic DNA Extraction Kit (2 plates)

FAPGE-96002 2 preps
EUR 337.2

96-well Plant Genomic DNA Extraction Kit (4 plates)

FAPGE-96004 4 preps
EUR 537.6

96-well Viral RNA/DNA Extraction Kit (1 plates)

FAVRE-96001 1 prep
EUR 232.8

96-well Viral RNA/DNA Extraction Kit (2 plates)

FAVRE-96002 2 preps
EUR 337.2

96-well Viral RNA/DNA Extraction Kit (4 plates)

FAVRE-96004 4 preps
EUR 537.6

96 well O' in 1 DNA Polymerase Premix

FYT201-96WL 96 Preps 23 µl x 96 Ask for price

96 WELL CLEAR PCR MICROPLATE

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EUR 174
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

100 BP DNA LADDER, 500UL PER KIT

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EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

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Description: Bioscience Mol Bio; DNA Ladder

96 Well Deep Well Storage

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EUR 194.94

96 Well Deep Well Storage

PCR0238 PK50
EUR 222.3

96-well Topoisomerase DNA Cleavage Assay Kit (enzyme not included)

TDC96K 96 assays
EUR 510.52
Description: This product includes 300 ul of 10 x reaction buffer, 30 ul of 10 x DNA, 260 ul of SDS solution, 30 ul of 100 mM ATP, 260 ul of proteinase K solutions, 10 ml of TDC matrix, 6 ml of rinse buffer, 500 ul of 10 x dye, a black receiver plate, a V-bottom reaction plate and a TDC filter plate. Topoisomerase is not included in the kit. A plate filtration device (see Note below) and a vacuum line are needed for the plate filtration process.

96-Well Topoisomerase DNA Decatenation Assay Kit (enzyme not included)

TDD96K 96 assays
EUR 526.61
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 110 ul of 10 mM ATP, 600 ul of 0.4 M EDTA, 260 ul of 20 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions. The assay buffer is optimized for bacterial topoisomerase IV. DNA decatenation enzyme is not included. This kit can be used for DNA decatenation assays of any bacterial topoisomerase IV (the parC-parE complex) enzymes or gyrases.

96-Well CometSlides

4253-096-03 1 Tests
EUR 170.88

96-Well Plate

1996-2 each
EUR 124.8

96 WELL PCR SEGMENTED PLATE

PCR-96-SG-C 10/pk
EUR 174
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

96 Well Low DWP Round Well

PCR0232 PK50
EUR 194.94

96-well E. coli Topo IV DNA Cleavage Assay Kit Plus

T4C96KE 96 assays
EUR 597.7
Description: This product includes all the components in TDC96K plus 26 ul of 100 x E. coli Topo IV.

Solid 96 well plates

MC15F-BIO 10 plates(2X5 plates in a transparent bag)
EUR 215.17
Description: Solid 96 well plates BIOTIN COATED Color:Clear blocking:Standard

Solid 96 well plates

MC15F-BIO-W 10 plates(2X5 plates in a transparent bag)
EUR 283.21
Description: Solid 96 well plates BIOTIN COATED Color:Clear blocking:Non proteic

Solid 96 well plates

MCB15F-BIO 10 plates(2X5 plates in a transparent bag)
EUR 221.98
Description: Solid 96 well plates BIOTIN COATED Color:Black blocking:Standard

Solid 96 well plates

MCB15F-BIO-W 10 plates(2X5 plates in a transparent bag)
EUR 287.75
Description: Solid 96 well plates BIOTIN COATED Color:Black blocking:Non proteic

Solid 96 well plates

MCW15F-BIO 10 plates(2X5 plates in a transparent bag)
EUR 221.98
Description: Solid 96 well plates BIOTIN COATED Color:White blocking:Standard

Solid 96 well plates

MCW15F-BIO-W 10 plates(2X5 plates in a transparent bag)
EUR 287.75
Description: Solid 96 well plates BIOTIN COATED Color:White blocking:Non proteic

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SD5011 1 UNIT
EUR 388.86

96-well microplate clamp

MIX1342 EACH
EUR 22.8

Mastercycler X50i 96-well

E6301000047 EACH
EUR 7977.72

Mastercycler X50l 96-well

E6303000044 EACH
EUR 7439.64

Mastercycler X50r 96-well

E6305000041 EACH
EUR 7977.72

Mastercycler X50s 96-well

E6311000045 EACH
EUR 9704.82

Mastercycler X50a 96-well

E6313000042 EACH
EUR 9165.6

Mastercycler X50p 96-well

E6315000040 EACH
EUR 9703.68

96-Well White Plates

M1354-2 each
EUR 157.2

96-Well Black Plates

M1355-2 each
EUR 157.2

EpiMag 96-Well Viral RNA Extraction Kit (High Throughput)

P-9109-96 96 samples
EUR 339.9

DNA-BIND™ PLATE, 96 WELL, CLEAR, FLAT 1/10

2525 1/pk
EUR 164.4
Description: Genomics; Genomic Plates

96 well filter plate (960ul each well)

SD5006 12UNIT
EUR 115.85

Deep Well Plate 96 Well 2.0 ML

AXYPDW20C PK50
EUR 181.26

96 Deep Well Plate Square Well V

PCR0246 PK50
EUR 258.78

Brand 96 Well Deep Well Plate-Stackable

BR701354-24EA PK24
EUR 144.78

UNIFILTER PLATE 96 WELL 800 UL/WELL

WHA77002803 PK25
EUR 823.08

96-Well Human Topo II DNA Decatenation Assay Kit Plus (enzyme included)

HDD96KE 96 assays
EUR 690.28
Description: This product includes the assay buffer, concatenated DNA, human topo II alpha, ATP, fluorescence dye, rinse buffer and a TDD filter plate for 96 assays of human topo II DNA decatenation reactions.

96-well E. coli Gyrase DNA Cleavage Assay Kit Plus (enzyme included)

T2C96KE 96 assays
EUR 597.7
Description: This product includes 300 ul of 10 x reaction buffer, 30 ul of 10 x DNA, 260 ul of SDS solution, 30 ul of 100 mM ATP, 260 ul of proteinase K solutions, 10 ml of TDC matrix, 6 ml of rinse buffer, 500 ul of 10 x dye, a black receiver plate, a V-bottom reaction plate, 26 ul of 100 x E. coli Gyrase and a TDC filter plate. A plate filtration device and a vacuum line are needed for the plate filtration process.

96-Well E. coli gyrase DNA Decatenation Assay Kit Plus (enzyme included)

T2DD-96KE 96 assays
EUR 591.41
Description: This product includes the assay buffer, concatenated DNA, E. coli gyrase, ATP, fluorescence dye, rinse buffer and a TDD filter plate for 96 assays of E. coli gyrase DNA decatenation reactions.

96-Well S. aureus gyrase DNA Decatenation Assay Kit Plus (enzyme included)

T2DD-96KS 96 assays
EUR 681.29
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 120 ul of 10 mM ATP, 100 ul of 50 x S. aureus gyrase, 600 ul of Stop solution (0.4 M EDTA), 500 ul of 10 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions.

CometAssay 96 Well ES Starter Kit

4253-096-ESK 1 Kit
EUR 3749.28

OxiSelect 96-Well Comet Assay Kit

STA-355 96 assays
EUR 512.4
Description: Our OxiSelect 96-Well Comet Assay Kits provide a higher-throughput way to screen for general DNA damage, regardless of the source or nature of the damage. Kits contain Comet Slides, reagents, and a fluorescent dye to visualize cells under an epifluorescence microscope.

OxiSelect 96-Well Comet Assay Kit

STA-355-5 5 x 96 assays
EUR 1959.6
Description: Our OxiSelect 96-Well Comet Assay Kits provide a higher-throughput way to screen for general DNA damage, regardless of the source or nature of the damage. Kits contain Comet Slides, reagents, and a fluorescent dye to visualize cells under an epifluorescence microscope.

96-Well ROCK Activity Assay Kit

STA-416 96 assays
EUR 1027.2
Description: Rho-associated Kinase (ROCK) mediates Rho signaling and reorganizes the actin cytoskeleton by phosphorylation of several substrates that contribute to the assembly of actin filaments and contractility. ROCK inactivates myosin phosphatase through the specific phosphorylation of myosin phosphatase target subunit 1 (MYPT1) at Thr-696, which results in an increase in the phosphorylated content of the 20-kDa myosin light chain (MLC20). Our 96-Well ROCK Activity Assay Kit uses a safe, non-radioactive format to measure the level of active Rho Kinase in cell or tissue lysates. The kit contains a strip-well plate pre-coated with recombinant MYPT1.

96-Well ROCK Activity Assay Kit

STA-416-5 5 x 96 assays
EUR 4228.8
Description: Rho-associated Kinase (ROCK) mediates Rho signaling and reorganizes the actin cytoskeleton by phosphorylation of several substrates that contribute to the assembly of actin filaments and contractility. ROCK inactivates myosin phosphatase through the specific phosphorylation of myosin phosphatase target subunit 1 (MYPT1) at Thr-696, which results in an increase in the phosphorylated content of the 20-kDa myosin light chain (MLC20). Our 96-Well ROCK Activity Assay Kit uses a safe, non-radioactive format to measure the level of active Rho Kinase in cell or tissue lysates. The kit contains a strip-well plate pre-coated with recombinant MYPT1.

96 WELL CLEAR PCR PLATE FOR ABI

PCR-96-AB-C 10/pk
EUR 200.4
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

96 WELL CLEAR PCR MICROPLATE. PRE-STERILIZED

PCR-96-C-S 10/pk
EUR 219.6
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

96 WELL CLEAR, FLAT TOP PCR MICROPLATE

PCR-96-FLT-C 25/pk
EUR 242.4
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

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PCR-96-FS-C 10/pk
EUR 174
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

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PCR-96-MB-C 10/pk
EUR 174
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

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R-96-PCR-FY 5/pk
EUR 142.8
Description: Micro Tubes; Racks Tubes - Axygen

Methylamp 96 DNA Modification Kit 

P-1008-1 96 Samples
EUR 253

Methylamp 96 DNA Modification Kit 

P-1008
  • EUR 416.70
  • EUR 253.00
  • 96 Samples
  • 96 Samples

96 Well Human Adult Normal Genomic DNA Plate - Peripheral Blood Leukocyte

D8234148-1 1 plate
EUR 307.2

1.2ML 96 WELL DEEP WELL PLATE HIGH CLARITY

P-DW-12-HC 5/pk
EUR 182.4
Description: Deep Well/Assay Plates - Axygen; Deep-well plates - Axygen

DEEP WELL PLATE 96 WELL 2.0 ML STERIL

AXYPDW20CS PK50
EUR 216.6

CrystalQuick, 96 Well, Square Well, Polystyrene, 40/CS

M-609101 40 PLATES
EUR 409
Description: CrystalQuick, 96 Well, Square Well, Polystyrene, 40/CS

CrystalQuick, 96 Well, Round Well, Polystyrene, 40/CS

M-609120 40 PLATES
EUR 515
Description: CrystalQuick, 96 Well, Round Well, Polystyrene, 40/CS

96-Well E. coli Topo IV DNA Decatenation Assay Kit Plus (enzyme included)

EDD96KE 96 assays
EUR 591.41
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 110 ul of 10 mM ATP, 8 ul of 1000 x E. coli topo IV, 600 ul of 0.4 M EDTA, 260 ul of 20 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions.

96-Well S. pneumoniae Topo IV DNA Decatenation Assay Kit Plus (enzyme included)

NDD96KE 96 assays
EUR 681.29
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 110 ul of 10 mM ATP, 8 ul of 1000 x S. pneumoniae topo IV, 600 ul of 0.4 M EDTA, 260 ul of 20 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions.

96-Well P. aeruginosa Topo IV DNA Decatenation Assay Kit Plus (enzyme included)

PDD96KE 96 assays
EUR 681.29
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 110 ul of 10 mM ATP, 8 ul of 1000 x P. aeruginosa topo IV, 600 ul of 0.4 M EDTA, 260 ul of 20 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions.

96-Well S. aureus Topo IV DNA Decatenation Assay Kit Plus (enzyme included)

SDD96KE 96 assays
EUR 681.29
Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 110 ul of 10 mM ATP, 8 ul of 1000 x S. aureus topo IV, 600 ul of 0.4 M EDTA, 260 ul of 20 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions.

96-Well E. coli Topo I DNA Decatenation Assay Kit Plus (enzyme included)

T1DD-96KE 96 assays
EUR 591.41
Description: This product includes the assay buffer, concatenated DNA, E. coli topo I, fluorescence dye, rinse buffer and a TDD filter plate for 96 assays of E. coli topo I DNA decatenation reactions.

96-well S. aureus Topo IV DNA Cleavage Assay Kit Plus (enzyme included)

T4C96KS 96 assays
EUR 777.46
Description: This product includes all the components in TDC96K plus 26 ul of 100 x S. aureus Topo IV.

Benchmark Beadblaster 96 Eva Cap Mat for 96 Well Deep Well Plate

HOM3232 EACH
EUR 98.04

Adapter for 96 well plate

3510147 1unit
EUR 6697.2

96 Well Half-Area Microplates

M1356-2 2 Plates
EUR 175.2

Tissue Culture 96-well Microplate

GR238004 Case of 50
EUR 330

96-well microplate sealer plastic

GR238031 Pack of 100
EUR 112.8

96-Well Rack, Reversible, Blue

R577-B 1 UNIT
EUR 64.86

96-Well Rack, Reversible, Green

R577-G 1 UNIT
EUR 64.86

96-Well Rack, Reversible, Natural

R577-N 1 UNIT
EUR 64.86

96-Well Rack, Reversible, Pink

R577-P 1 UNIT
EUR 64.86

96-Well Rack, Reversible, Purple

R577-V 1 UNIT
EUR 64.86

96-Well Rack, Reversible, Yellow

R577-Y 1 UNIT
EUR 64.86

Croplate 96 Well 800ul 0.45um

77002808 EACH
EUR 688.56

Plate 96 Well Immulon II

3455 PK50
EUR 243.96

Spheroid Microplate 96 well Sterile

4515 PK5
EUR 224.58

Sarstedt 96 well suspension (83.3926.500)

4653305 PK50
EUR 91.2

96 well PCR plate ns

AXY2164 PK50
EUR 220.02

Corning 96 Well Strip Ejector

2578 PK5
EUR 77.52

Nunc 96 Well caps Sterilelicone

276011 PK50
EUR 1104.66

Greiner polystyrene 96 well plates

M2311-100EA PK100
EUR 166.44

Greiner polystyrene 96 well plates

M2811-100EA PK100
EUR 132.24

Greiner polypropylene 96 well plates

M7310-100EA PK100
EUR 178.98

Greiner polypropylene 96 well plates

M8185-100EA PK100
EUR 178.98

Greiner polypropylene 96 well plates

M9060-100EA PK100
EUR 174.42

Dot blot manifold 96 well

CSLD96 EACH
EUR 750.12

Black 96 Well Plate, 1EA

X025-1EA 1EA
EUR 87.6

Deep Well Block 96 Positions

CHR3578 EACH
EUR 127.68

96 Well MPlate Sealing Strip

CHR5886 PK24
EUR 52.44

Greiner 96 well microplate white

G655075 PK40
EUR 55.63

Greiner 96 well microplate black

G655076 PK40
EUR 55.63

Greiner 96 well microplate polystyrene

G655101 PK100
EUR 52.78

96 Well Microplate Round Wells

PCR0224 PK50
EUR 143.64

96 Round Well Silicone Mat

PCR0268 PK50
EUR 201.78

Fastplate 96 Well Semi Skirted

PCR1194 PK50
EUR 362.52

Fastplate 96 Well Semi Skirted

PCR1196 PK10
EUR 35.23

Fastplate 96 Well Semi Skirted

PCR1198 PK50
EUR 171

Fastplate 96 Well Semi Skirted

PCR1202 PK50
EUR 237.12

Fastplate 96 Well Semi Skirted

PCR1204 PK10
EUR 35.23

480 96 Well Semi Skirted

PCR1206 PK50
EUR 249.66

480 96 Well Semi Skirted

PCR1208 PK50
EUR 178.98

96 Well Roche Style Qpcr

PCR1212 PK50
EUR 255.36

96 Well Semi Skirted Plate

PCR1216 PK50
EUR 150.48

96 Well Skirted PCR Plate

PCR1236 PK50
EUR 299.82

Hellma Quartz 96 Well Microplate

CEL1732 EACH
EUR 4186.08

Replicator 96-well Bela rt

Z370819-1EA EACH
EUR 29.87

PCR Box Natural 96 Well

RAC0490 PK5
EUR 77.52

PCR Box Blue 96 Well

RAC0492 PK5
EUR 77.52

PCR Box Green 96 Well

RAC0494 PK5
EUR 77.52

PCR Box Assorted 96 Well

RAC0498 PK5
EUR 77.52

96-Well Protein Folding Plate

PFS096 kit
EUR 347.84
Description: This product includes one 96-well plate with 96 protein folding solutions, 0.5 ml in each well of the mother plate; 1.4 ml of Inclusion Body Solubilizer; 4 ml of Neutralizer. Each experiment uses 0.1 ml of the solutions from the mother plate. Each mother plate contains 0.5 ml of solutions in each well and can be used for multiple experiments of folding various proteins.

Avidin CovaLinked 96-well Plates

6521-5 each
EUR 306

Streptavidin coated 96-well Plate

6523-5 each
EUR 392.4

illustra GFx 96 Purification Kit 10 x 96 well plates

28903445 EACH
EUR 1576.62

CytoSelect 96-well Leukocyte-endothelium Adhesion Kit

CBA-210 100 assays
EUR 692.4
Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Endothelium Adhesion Assays provide a robust system for the quantitative determination of interactions between leukocytes or tumor cells and endothelium. Adherent cells can be easily quantified on a fluorescence plate reader.

CytoSelect 96-well Leukocyte-epithelium Adhesion Kit

CBA-211 100 assays
EUR 692.4
Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Leukocyte Epithelium Adhesion Assay provides a robust system for the quantitative determination of interactions between leukocytes and epithelium. Adherent cells can be easily quantified on a fluorescence plate reader.

96-Well Plate PCR Products Purification Kit

BS365 5XPlates, 480prep
EUR 300.37

96-Well Plate PCR Products Purification Kit

BS3652 2xPlates, 192prep
EUR 186.19

96-well GEL Purification Kit (1 prep)

FAGKE-96001 1 prep
EUR 189.6

96-well GEL Purification Kit (2 prep)

FAGKE-96002 2 preps
EUR 255.6

96-well GEL Purification Kit (4 prep)

FAGKE-96004 4 preps
EUR 380.4

96-well Total RNA Kit (1 plates)

FATRE-96001 1 prep
EUR 232.8

96-well Total RNA Kit (2 plates)

FATRE-96002 2 preps
EUR 337.2

96-well Total RNA Kit (4 plates)

FATRE-96004 4 preps
EUR 537.6
The predictions recommend that these therapies for lung supply ought to ideally be delivered in a sustained launch formulation with excessive solubility for optimum native publicity in lungs for efficacy, with fast systemic clearance in plasma for diminished danger of undesirable systemic antagonistic results. This work exhibits the potential advantages of BPMX and the position it may play to help drug discovery and growth in pulmonary supply.

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