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Glycine additive facilitates site-specific glycosylation profiling of biopharmaceuticals by ion-pairing hydrophilic interaction chromatography mass spectrometry

Glycine additive facilitates site-specific glycosylation profiling of biopharmaceuticals by ion-pairing hydrophilic interaction chromatography mass spectrometry

Many biotherapeutics corresponding to monoclonal antibodies (mAb) and Fc-domain fusion proteins include heterogeneous glycan contents at one or a number of glycosylation website(s). Website-specific glycan profile characterization is important for monitoring the standard of those molecules throughout totally different phases of drug improvement. Hydrophilic interplay chromatography (HILIC) as an orthogonal separation methodology to reversed-phase liquid […]

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Molecular Biology of Basal and Squamous Cell Carcinomas

Molecular Biology of Basal and Squamous Cell Carcinomas     The prevalent keratinocyte-derived neoplasms of the pores and skin are basal cell carcinoma and squamous cell carcinoma. Each so-called non-melanoma pores and skin cancers comprise the commonest cancers in people by far. Frequent danger elements for each tumor entities embrace solar publicity, DNA restore deficiencies resulting in […]