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Glycine additive facilitates site-specific glycosylation profiling of biopharmaceuticals by ion-pairing hydrophilic interaction chromatography mass spectrometry

Glycine additive facilitates site-specific glycosylation profiling of biopharmaceuticals by ion-pairing hydrophilic interaction chromatography mass spectrometry

Many biotherapeutics corresponding to monoclonal antibodies (mAb) and Fc-domain fusion proteins include heterogeneous glycan contents at one or a number of glycosylation website(s). Website-specific glycan profile characterization is important for monitoring the standard of those molecules throughout totally different phases of drug improvement. Hydrophilic interplay chromatography (HILIC) as an orthogonal separation methodology to reversed-phase liquid […]

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Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic 

Propofol Impacts Non-Small-Cell Lung Most cancers Cell Biology By Regulating the miR-21/PTEN/AKT Pathway In Vitro and In Vivo   Background: Propofol is a standard sedative-hypnotic drug historically used for inducing and sustaining basic anesthesia. Current research have drawn consideration to the nonanesthetic results of propofol, however the potential mechanism by which propofol suppresses non-small-cell lung most cancers (NSCLC) development has […]