
Background: One of many main challenges in pediatric remedy is the dearth of appropriate drug preparations particularly designed and marketed for kids. A lot of the FDA accredited drug formulations for adults haven’t been accredited to be used in pediatric sufferers. Scarcity of appropriate pediatric dosage info usually leads well being professionals to make use of grownup formulations in an off-label method. The goal of this work was to evaluation the protection and biopharmaceutical challenges of generally discovered excipients in off-label pediatric formulations in addition to to indicate the present progress to alleviate pediatric toxicity associated to excipients.
Strategies: Analysis findings and medical case experiences had been searched from credible sources together with Scopus, PubMed, OVID, Google Scholar, Embase, Cochrane Library, and Internet of Science.
Outcomes: As a number of research and medical case experiences have revealed, off-label grownup formulations utilization causes pediatric sufferers to grow to be uncovered to doubtlessly dangerous excipients, that are important parts of drug merchandise. Along with their toxicities, a few of the excipients have an effect on the biopharmaceutical property of various medicine. Immature organ and physique composition, massive physique floor space and slower metabolism and elimination capabilities of pediatrics are the principle causes of toxicities related to completely different excipients. Latest research have additionally proven that good progress is being made to develop protected and appropriate excipients for pediatric use.
Conclusion: A threat and profit evaluation must be executed earlier than utilizing off-label formulation as excipients trigger delicate to extreme toxicities and biopharmaceutical issues to pediatric sufferers.
Towards a Higher Understanding of Bioassays for the Improvement of Biopharmaceuticals by Exploring the Construction-Antibody-Dependent Mobile Cytotoxicity Relationship in Human Main Cells
Pharmaceutical manufacturing depends on rigorous strategies of high quality management of medicine and particularly of the physico-chemical and practical characterizations of monoclonal antibodies.
To that finish, sturdy bioassays are fairly often restricted to reporter gene assays and using immortalized cell strains which might be alleged to mimic immune cells resembling pure killer (NK) cells to the detriment of main supplies, that are appreciated for his or her organic validity however are additionally tough to take advantage of because of the nice variety between people. Right here, we characterised the phenotype of the peripheral blood circulating cytotoxic cells of 30 wholesome donors, particularly the repertoire of cytotoxic markers, utilizing circulate cytometry. In parallel, we characterised the antibody-dependent mobile cytotoxicity (ADCC) effector features of those main cells by measuring their cytolytic exercise towards a most cancers cell-line expressing HER2 within the presence of trastuzumab and close to FCGR3A genotype.
We couldn’t set up a correlation or grouping of people utilizing the info generated from complete peripheral blood mononuclear cells, nevertheless the isolation of the CD56-positive inhabitants, which consists not solely of NK cells but in addition of pure killer T (NKT) and γδ-T cells, in addition to subsets of activated cytotoxic T cells, monocytes and dendritic cells, made it potential to standardize the parameters of the ADCC and improve the general practical avidity with out nevertheless eliminating the inter-individual variety. Lastly, using main CD56+ cells in ADCC experiments evaluating glycoengineered variants of trastuzumab was conclusive to check the bounds of this kind of ex vivo system. Though the effector features of CD56+ cells mirrored to some extent the in vitro receptor binding properties and cytolytic exercise knowledge utilizing NK92 cells, as beforehand printed, reaching a practical avidity plateau may restrict their use in a top quality management framework.

Insights from Pharmaceutical Biotechnology into Phenolic Biopharmaceuticals towards COVID-19
Background: The COVID-19 pandemic had contaminated greater than 3.5M folks all over the world and greater than 250Okay folks died in 187 nations by Could 2020. The causal agent of this illness is a coronavirus whose onset of signs to demise vary from 6 to 41 days with a median of 14 days. This era depends on a number of elements such because the presence of comorbidities, age and the effectivity of the innate or adaptive immune responses. The effectors mechanisms of each forms of immune responses depend upon the pathogen concerned. Within the case of a viral an infection, the innate immune response might strategy the dangerous virus by means of sample recognition receptors inducing an antiviral state. However, the adaptive immune response prompts antibody manufacturing to neutralize or remove the virus.
11-Well Centrifuge Tube Box |
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R011-N | Bio Basic | 1 UNIT | EUR 61.82 |
12-Well Centrifuge Tube Box |
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R012-N | Bio Basic | 1 UNIT | EUR 62.62 |
24-Well Centrifuge Tube Box |
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R024-N | Bio Basic | 1 UNIT | EUR 63.13 |
Block, 20x10mm test tubes or 20x2.0ml centrifuge tubes |
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BCM1412-BSW10 | Bio Basic | 1 pcs, 1 UNIT | EUR 233.21 |
Block, 20x10mm test tubes or 20x2.0ml centrifuge tubes |
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BSW10 | Benchmark Scientific | 1 PC | EUR 144.7 |
5-Well Centrifuge Tube Box (3cc Glass Vials) |
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R006-G | Bio Basic | 1 UNIT | EUR 61.82 |
5-Well Centrifuge Tube Box (10cc Glass Vials) |
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R007-G | Bio Basic | 1 UNIT | EUR 61.82 |
5-Well Centrifuge Tube Box (1.5ml To 2ml Tubes) |
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R005-G | Bio Basic | 1 UNIT | EUR 61.57 |
96-Well Plate Plasmid DNA Mini-Preps Kit (Vacuum Based) |
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B814152-0002 | Bio Basic | 2XPlates, 2XPlates | EUR 186.19 |
96-Well Plate Plasmid DNA Mini-Preps Kit (Vacuum Based) |
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B814152-0005 | Bio Basic | 5XPlates, 5XPlates | EUR 300.37 |
Cool rack 9 wells for 15ml centrifuge tubes |
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HOM2740 | Scientific Laboratory Supplies | EACH | EUR 996.17 |
Cool rack 4 wells for 50ml centrifuge tubes |
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HOM2742 | Scientific Laboratory Supplies | EACH | EUR 996.17 |
Lab Basics Centrifuge 12x1.5/2.0ml |
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SLS4600 | Scientific Laboratory Supplies | EACH | EUR 1708.8 |
High Speed Centrifuge 15, 500rpm/16, 100Xg |
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BCM1923 | Bio Basic | 1 pcs, 1 UNIT | EUR 1967.27 |
Block, 24 x 1.5ml or 2.0ml centrifuge tubes |
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BCM1412-BSW1520 | Bio Basic | 1 pcs, 1 UNIT | EUR 233.21 |
Block, 24 x 1.5ml or 2.0ml centrifuge tubes |
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BSW1520 | Benchmark Scientific | 1 PC | EUR 144.7 |
Conical Centrifuge Tube, PP/HDPE, 15ml, RCF 13000xg, 500/case |
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SP61126 | Bio Basic | 1CS, 500UNIT | EUR 183.44 |
Conical Centrifuge Tube, PP/HDPE, 50ml, RCF 14000Xg, 500/case |
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SP61161 | Bio Basic | 1CS, 500UNIT | EUR 210.76 |
Block, 15 x 1.5ml or 2.0ml centrifuge tubes (conical) |
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BCM1405-B1520 | Bio Basic | 1 pcs, 1 UNIT | EUR 194.76 |
Block, 15 x 1.5ml or 2.0ml centrifuge tubes (conical) |
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BSH100-1520 | Benchmark Scientific | 1 PC | EUR 109.3 |
Block, 8x5ml centrifuge tubes, for MultiTherm Touch |
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H5100-5MT | Benchmark Scientific | 1 each | EUR 364 |
Culture/Centrifuge Tube, PP, with attached cap, 7mL, 15x60mm |
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C2595-7 | MTC Bio | 200/pack | EUR 115.9 |
Description: Culture/Centrifuge Tube PP |
Centrifuge Tube |
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C1005-T5*-Clear | Benchmark Scientific | 1 PC | EUR 117.16 |
Mini Centrifuge |
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CTFG | BioAssay Systems | 1 unit | EUR 39 |
Description: Small centrifuge used for preparation of fish and wine samples for use with the Histamine Quick Test Strips. Quantity: 1. |
Centrifuge Rotors |
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abx725046-FixedAngleRotor450ml | Abbexa | Fixed Angle Rotor; 4 × 50 ml | EUR 414 |
Centrifuge Rotors |
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abx725046-FixedAngleRotor650ml | Abbexa | Fixed Angle Rotor; 6 × 50 ml | EUR 435.6 |
Centrifuge Rotors |
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abx725046-FixedAngleRotor815ml | Abbexa | Fixed Angle Rotor; 8 × 15 ml | EUR 414 |
Centrifuge Rotors |
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abx725046-SwingOutRotor450ml | Abbexa | Swing-Out Rotor; 4 × 50 ml | EUR 456 |
Centrifuge Rotors |
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abx725046-SwingOutRotor815ml | Abbexa | Swing-Out Rotor; 8 × 15 ml | EUR 414 |
F-32x0.2 rotor for centrifuge 5420 |
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E5495404007 | Scientific Laboratory Supplies | EACH | EUR 546 |
Centrifuge 5920R no rotor |
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E5948000060 | Scientific Laboratory Supplies | EACH | EUR 12007.2 |
Clinical Centrifuge |
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abx725010-1Unitwith6Slot1015mlFixedAngleAutoclavableRotor | Abbexa | 1 Unit with 6 Slot × 10/15 ml Fixed Angle Autoclavable Rotor | EUR 1333.2 |
Clinical Centrifuge |
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abx725010-1Unitwith6Slot1015mlFixedAngleAutoclavableRotor8Slot1015mlFixedAngleAutoclavableRotor | Abbexa | 1 Unit with 6 Slot × 10/15 ml Fixed Angle Autoclavable Rotor + 8 Slot × 10/15 ml Fixed Angle Autoclavable Rotor | EUR 1479.6 |
Clinical Centrifuge |
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abx725010-1Unitwith8Slot1015mlFixedAngleAutoclavableRotor | Abbexa | 1 Unit with 8 Slot × 10/15 ml Fixed Angle Autoclavable Rotor | EUR 1395.6 |
FA-24x2 rotor for centrifuge 5420 |
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E5495400001 | Scientific Laboratory Supplies | EACH | EUR 690 |
Microtube Centrifuge |
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CEN0200 | Scientific Laboratory Supplies | EACH | EUR 1408.74 |
COMPACT CENTRIFUGE, 120VOLT |
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6755 | CORNING | 1/pk | EUR 1777.2 |
Description: Lab Equipment; General Purpose Centrifuges (affliated brand) |
DB 2.2 Single block for 5 x 50ml conical centrifuge tubes or 6; 12/13 or 25mm test tube combinations |
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BLO6034 | Scientific Laboratory Supplies | EACH | EUR 163.2 |
Laboratory Centrifuge |
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abx725016-1Unit | Abbexa | 1 Unit | EUR 3588 |
Hematocrit Centrifuge |
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abx725029-1Unit | Abbexa | 1 Unit | EUR 1813.2 |
SLS Micro Centrifuge 7000rpm |
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SLS1660 | Scientific Laboratory Supplies | EACH | EUR 240 |
IKA Mini centrifuge |
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CEN4606 | Scientific Laboratory Supplies | EACH | EUR 384 |
SL4 Plus Centrifuge |
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75009912 | Scientific Laboratory Supplies | EACH | EUR 8208 |
CoolRack for 1 x 250ml conical centrifuge tube |
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432063 | Scientific Laboratory Supplies | EACH | EUR 416.4 |
Centrifuge 5420 without rotor |
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E5420000369 | Scientific Laboratory Supplies | EACH | EUR 1842 |
Bottle Centrifuge Sb 250Ml |
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3123-0250 | Scientific Laboratory Supplies | PK4 | EUR 110.4 |
SL4R Plus Centrifuge |
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75009927 | Scientific Laboratory Supplies | EACH | EUR 13219.2 |
Centrifuge 5910 Ri S-4x750 |
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E5943000564 | Scientific Laboratory Supplies | EACH | EUR 14476.8 |
Programmable Centrifuge |
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abx725003-1Unitwith12slot152mlMicrotubeRotor | Abbexa | 1 Unit with 12 slot 1.5 × 2ml Microtube Rotor | EUR 1750.8 |
Programmable Centrifuge |
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abx725003-1Unitwith12slot152mlMicrotubeRotor2802mlPCRstripRotor | Abbexa | 1 Unit with 12 slot 1.5 × 2ml Microtube Rotor + 2 × 8 × 0.2ml PCR strip Rotor | EUR 1980 |
Thermo SL8R Centrifuge |
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75007224 | Scientific Laboratory Supplies | EACH | EUR 7713.6 |
Eppendorf Centrifuge 5810 Bundle |
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E5810000365 | Scientific Laboratory Supplies | EACH | EUR 6948 |
Eppendorf Centrifuge 5810 Bundle |
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E5810000460 | Scientific Laboratory Supplies | EACH | EUR 7812 |
Centrifuge 5920R highcap package |
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E5948000260 | Scientific Laboratory Supplies | EACH | EUR 15129.6 |
Bottle Centrifuge Pp 250 Ml |
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3141-0250 | Scientific Laboratory Supplies | PK4 | EUR 132 |
Bottle Centrifuge Pp 450 Ml |
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3141-0500 | Scientific Laboratory Supplies | PK4 | EUR 172.8 |
TUBE ROTOR FOR MINI CENTRIFUGE |
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6770-RT | CORNING | 1/pk | EUR 80.4 |
Description: Lab Equipment; General Purpose Centrifuges (affliated brand) |
Block for 5mL centrifuge tubes |
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MIX7218 | Scientific Laboratory Supplies | EACH | EUR 634.8 |
Block for 5ml centrifuge tubes |
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H5000-5MT | Benchmark Scientific | 1 PC | EUR 479.8 |
Eppendorf Centrifuge 5702R Bundle |
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E5703000360 | Scientific Laboratory Supplies | EACH | EUR 5977.2 |
Eppendorf Centrifuge 5804R Bundle |
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E5805000365 | Scientific Laboratory Supplies | EACH | EUR 8080.8 |
Eppendorf Centrifuge 5810R Bundle |
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E5811000360 | Scientific Laboratory Supplies | EACH | EUR 10890 |
Eppendorf Centrifuge 5810R Bundle |
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E5811000465 | Scientific Laboratory Supplies | EACH | EUR 10982.4 |
Centrifuge Micro FC5515 |
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CEN2600 | Scientific Laboratory Supplies | EACH | EUR 2485.2 |
Centrifuge Multi FC5706 |
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CEN2628 | Scientific Laboratory Supplies | EACH | EUR 1728 |
Centrifuge Multi FC5816 |
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CEN2650 | Scientific Laboratory Supplies | EACH | EUR 5018.4 |
Centrifuge Multi FC5718 |
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CEN2654 | Scientific Laboratory Supplies | EACH | EUR 4258.8 |
Centrifuge Multi FC5714 |
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CEN2656 | Scientific Laboratory Supplies | EACH | EUR 3370.8 |
Centrifuge 5920R 15/50mL package |
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E5948000365 | Scientific Laboratory Supplies | EACH | EUR 14616 |
Centrifuge 5920R 15/50mL package |
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E5948000460 | Scientific Laboratory Supplies | EACH | EUR 14618.4 |
Centrifuge 5920R 15/50mL package |
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E5948000560 | Scientific Laboratory Supplies | EACH | EUR 14878.8 |
Centrifuge Micro FC5515R |
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CEN2602 | Scientific Laboratory Supplies | EACH | EUR 5457.6 |
Centrifuge Multi FC5816R |
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CEN2648 | Scientific Laboratory Supplies | EACH | EUR 8959.2 |
Centrifuge Multi FC5718R |
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CEN2652 | Scientific Laboratory Supplies | EACH | EUR 7200 |
Greiner centrifuge tubes |
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T1943-1000EA | Scientific Laboratory Supplies | PK1000 | EUR 366 |
Greiner centrifuge tubes |
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T2193-300EA | Scientific Laboratory Supplies | PK300 | EUR 206.28 |
X4F Ventilated Centrifuge |
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75009930 | Scientific Laboratory Supplies | EACH | EUR 13884 |
Personal Micro Centrifuge |
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abx725001-1Unit | Abbexa | 1 Unit | EUR 518.4 |
Sigma Centrifuge 1-14 cw 24place rotor |
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10016 | Scientific Laboratory Supplies | EACH | EUR 2194.71 |
Oil Centrifuge Tube 100ml |
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F87990 | Scientific Laboratory Supplies | PK2 | EUR 156 |
Centrifuge 5920R no rotor- IVD Only |
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E5948000069 | Scientific Laboratory Supplies | EACH | EUR 12601.2 |
Nunc 14ml Centrifuge Tube |
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150268 | Scientific Laboratory Supplies | PK500 | EUR 231.6 |
EBA 280 Compact Centrifuge |
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CEN0177 | Scientific Laboratory Supplies | EACH | EUR 3786 |
Nunc Centrifuge Tube 11mm |
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337846 | Scientific Laboratory Supplies | PK480 | EUR 445.2 |
Centrifuge Tube ASTM 100ml |
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362338 | Scientific Laboratory Supplies | PK2 | EUR 169.2 |
96-Well Vacuum System |
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SD5011 | Bio Basic | 1 UNIT | EUR 388.86 |
Centrifuge 5420 with rotor IVD ONLY |
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E5420000067 | Scientific Laboratory Supplies | EACH | EUR 2392.8 |
12 Mini Centrifuge 100-240V (US plug) |
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BCM1746 | Bio Basic | 1 pcs, 1 UNIT | EUR 680.54 |
EBA 200 Clinical Centrifuge |
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CEN0171 | Scientific Laboratory Supplies | EACH | EUR 1994.4 |
IKA G-L Midi Centrifuge |
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CEN4608 | Scientific Laboratory Supplies | EACH | EUR 1134 |
X4RF Refrigerated Centrifuge |
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75009936 | Scientific Laboratory Supplies | EACH | EUR 20054.4 |
Centrifuge 5420 with rotor FA-24x2 |
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E5420000164 | Scientific Laboratory Supplies | EACH | EUR 2109.6 |
Centrifuge tube 1.5ml natural |
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CEN9308M | Scientific Laboratory Supplies | PK500 | EUR 15.6 |
Hettich Centrifuge Mikro 220 |
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CEN0111 | Scientific Laboratory Supplies | EACH | EUR 4654.8 |
High Speed Micro Centrifuge |
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abx725025-1Unitwith12slot152mlMicrotubeRotor2802mlPCRStripRotor | Abbexa | 1 Unit with 12 slot × 1.5/2ml Microtube Rotor + 2 × 8 × 0.2ml PCR Strip Rotor | EUR 1584 |
High Speed Micro Centrifuge |
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abx725025-1Unitwith24tube45mmlengthHematocritRotor | Abbexa | 1 Unit with 24 tube × 45 mm length Hematocrit Rotor | EUR 1353.6 |
High Speed Micro Centrifuge |
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abx725025-1Unitwith2802mlPCRstripRotor | Abbexa | 1 Unit with 2 × 8 × 0.2ml PCR strip Rotor | EUR 1353.6 |
Bucket Adaptors 5804 Centrifuge |
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E5804787005 | Scientific Laboratory Supplies | PK2 | EUR 192 |
Centrifuge adapter pack for 7ml tube |
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HOM1028 | Scientific Laboratory Supplies | EACH | EUR 124.8 |
Eppendorf Centrifuge 5430 without Rotor |
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E5427000060 | Scientific Laboratory Supplies | EACH | EUR 3187.75 |
Eppendorf Centrifuge 5702 without rotor |
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E5702000065 | Scientific Laboratory Supplies | EACH | EUR 2026.8 |
Eppendorf Centrifuge 5804 without rotor |
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E5804000060 | Scientific Laboratory Supplies | EACH | EUR 3967.2 |
Eppendorf Centrifuge 5810 without rotor |
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E5810000060 | Scientific Laboratory Supplies | EACH | EUR 5210.4 |
Centrifuge 5420 without rotor IVD ONLY |
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E5420000261 | Scientific Laboratory Supplies | EACH | EUR 1964.4 |
CapLock 0.5mL Centrifuge Tubes |
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ARG1782 | Scientific Laboratory Supplies | PK500 | EUR 65.8 |
CapLock 1.5mL Centrifuge Tubes |
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ARG1808 | Scientific Laboratory Supplies | PK1000 | EUR 117.5 |
Hettich Centrifuge Rotina 380 |
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CEN5010 | Scientific Laboratory Supplies | EACH | EUR 7107.6 |
Hettich Centrifuge Rotina 420 |
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CEN5030 | Scientific Laboratory Supplies | EACH | EUR 7926 |
Hettich Centrifuge Mikro 220R |
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CEN0113 | Scientific Laboratory Supplies | EACH | EUR 8248.8 |
Thermo Micro CL21 Centrifuge |
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75002465 | Scientific Laboratory Supplies | EACH | EUR 3508.8 |
Eppendorf 5702 Centrifuge Bundle |
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E5702000365 | Scientific Laboratory Supplies | EACH | EUR 3094.8 |
COMPACT CENTRIFUGE, 230 VOLT UK PLUG |
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6758 | CORNING | 1/pk | EUR 1777.2 |
Description: Lab Equipment; General Purpose Centrifuges (affliated brand) |
COMPACT CENTRIFUGE, 230 VOLT EU PLUG |
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6759 | CORNING | 1/pk | EUR 1777.2 |
Description: Lab Equipment; General Purpose Centrifuges (affliated brand) |
DB 2.1 Single block for 12 x 15ml conical centrifuge tubes |
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BLO6032 | Scientific Laboratory Supplies | EACH | EUR 163.2 |
Eppendorf Centrifuge 5702R without rotor |
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E5703000060 | Scientific Laboratory Supplies | EACH | EUR 4803.6 |
Eppendorf Centrifuge 5810R without rotor |
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E5811000065 | Scientific Laboratory Supplies | EACH | EUR 8732.4 |
Hettich Centrifuge Rotina 380R |
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CEN5012 | Scientific Laboratory Supplies | EACH | EUR 11211.6 |
Hettich Centrifuge Rotina 420R |
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CEN5032 | Scientific Laboratory Supplies | EACH | EUR 12490.8 |
Tubes Centrifuge 15ml Conical |
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CEN9202 | Scientific Laboratory Supplies | PK500 | EUR 230.4 |
Pro Research K241R Centrifuge |
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CEN0164 | Scientific Laboratory Supplies | EACH | EUR 4863.36 |
Thermo Micro CL17R Centrifuge |
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75002455 | Scientific Laboratory Supplies | EACH | EUR 6355.2 |
Thermo Micro CL21R Centrifuge |
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75002470 | Scientific Laboratory Supplies | EACH | EUR 7462.8 |
EBA 280 S Compact Centrifuge |
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CEN0178 | Scientific Laboratory Supplies | EACH | EUR 5384.4 |
Programmable Clinical Centrifuge |
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abx725028-1Unitwith16Slot10mlFixedAngleRotor | Abbexa | 1 Unit with 16 Slot × 10 ml Fixed Angle Rotor | EUR 1771.2 |
Phenolics are plant secondary metabolites with many organic actions for vegetation and people towards an infection. Chemical modification of proteins might improve their organic properties; thus, a protein of medical curiosity, as an illustration, a viral protein can be utilized as scaffold to construct a biopharmaceutical conjugated or complexated with phenolics exhibiting structural complexity or organic actions to realize efficient phenolic-protein-based therapeutics like vaccine adjuvant complexes, immunogen conjugates, and antiviral conjugates.